08 Dec 2025
2h 8m

#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.

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The Peter Attia Drive

In this episode of The Drive, Peter Attia interviews Dom D'Agostino, a neuroscientist and professor, about metabolic therapies, including ketogenic diets, exogenous ketones, and hyperbaric oxygen. They discuss the differences between nutritional and supplemental ketosis, how to achieve clinical ketosis while maintaining adequate protein intake, and the challenges of transitioning to a ketogenic diet. They also delve into the landscape of exogenous ketones, including salts versus esters, and the potential of ketogenic diets for cancer and neurodegenerative diseases. Additionally, they touch on hyperbaric oxygen chambers, fasting, ketones as tools for cognition and inflammation, and the carnivore diet.

Outlines

Part 1: Introduction to Ketosis

Part 2: Ketogenic Diet - Details and Applications

Part 3: Ketogenic Diet - Therapeutic Uses

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