‣ Book Your COMPLEMENTARY CONSULATION and CALORIE CALCULATION call:- how much & what to eat🍴🌮- exercise & lifestyle recommendations🚶‍♀️🏋🏽‍♀️- specific resources to support you on your journey📕https://calendly.com/d/2p8-mxx-dgf/free-consultation-call-zoom⁠⁠⁠⁠⁠⁠‣ Take The Fat Loss Fix Quiz: https://1ck2gu1qfir.typeform.com/menometabolism

In this episode, we’re diving into how methylation and the MTHFR gene impact your metabolism, detox pathways, and fat loss — especially in women over 40.

When methylation isn’t working properly, your body struggles to:

- Detoxify estrogen efficiently (hello, estrogen dominance + stubborn fat)

- Clear toxins and inflammation that block thyroid function

- Activate key nutrients like folate, B12, and choline (needed for liver and brain health)

- Produce neurotransmitters that stabilize mood and motivation

In other words — your “fat-burning pathways” aren’t just about food or workouts.

They’re biochemical.

And when they’re blocked, your body gets stuck in protect mode — holding onto fat, toxins, and frustration.

We’ll cover:

✅ What methylation actually is (in normal-person language)

✅ What the MTHFR gene does — and why 40–50% of women carry it

✅ How it affects detox, hormones, and metabolism in perimenopause and menopause

✅ Key nutrients that support methylation (and which forms to look for)

✅ How to improve methylation naturally to reactivate fat burning

If you’ve ever been told your labs are “normal” but you know something’s off — this episode will help you connect the dots between your genes, hormones, and metabolism.TIMESTAMPS:

(00:00) – Intro: What Is Methylation & Why It Matters

(01:45) – How Methylation Affects Fat Burning & Hormone Balance

(06:16) – The Link Between Methylation, Stress & Fat Storage

(16:01) – Why Women Struggle More With Methylation

(23:48) – How Poor Methylation Shows Up in Midlife

(28:25) – Hormones, Stress & Environmental Load

(44:24) – MTHFR Genes, Mood & Detox Explained

(51:48) – How to Support Methylation Naturally

(58:59) – Final Thoughts: Focus on the Big Rocks

CONNECT WITH ME ONLINE:‣ Book a COMPLEMENTARY CONSULATION and CALORIE CALCULATION call:- how much you should eat🍴- what you should eat 🌮- exercise adjustments🏋🏽‍♀️- lifestyle recommendations🚶‍♀️- specific resources to support you on your journey📕https://calendly.com/d/2p8-mxx-dgf/free-consultation-call-zoom⁠⁠⁠⁠⁠⁠‣ Check out our BRAND NEW workout subscription: ⁠⁠⁠⁠⁠⁠https://www.trainerize.me/profile/vitalityoet/?planGUID=b020a7cf27f6453b9d29ca3dc9bbaf37&mode=checkout⁠⁠⁠⁠⁠⁠‣ Join our community! Metabolism and Menopause by Vitality - Secrets for Fat Loss: ⁠⁠⁠⁠⁠⁠https://m.facebook.com/groups/969761266958379⁠⁠⁠⁠⁠⁠‣ Apply for coaching with us! - ⁠⁠⁠⁠⁠⁠https://calendly.com/d/386-k9q-4cg/coaching-application-call-zoom⁠⁠⁠⁠⁠⁠‣ Our Website! - https://www.vitalityoet.com/‣ Learn more about DUTCH hormone testing with VitalityOET - ⁠⁠⁠⁠⁠⁠https://www.loom.com/share/a567d01c12b44aaf855dcf3d9049d537⁠⁠⁠⁠⁠⁠‣ Menopause supplements (use code VITALITY10 for 10% off your order) - ⁠⁠⁠⁠⁠⁠https://shop.nutritiondynamic.com/collections/all⁠⁠⁠⁠⁠⁠‣ Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/vitalityoet.stephanie⁠⁠⁠⁠⁠⁠‣ Listen the Podcast on Apple or Spotify: Spotify: https://open.spotify.com/show/7erYECmZG7JHyzFePoaybe?si=ad89a3c7d408496eApple: https://podcasts.apple.com/us/podcast/the-metabolism-and-menopause-podcast/id1683220450‣ All other links: ⁠⁠⁠⁠⁠⁠https://stan.store/vitalityoetstephanie⁠⁠⁠⁠⁠⁠‣ Email: ⁠⁠⁠⁠⁠⁠stephanie@vitalityoet.com⁠⁠⁠⁠⁠⁠----© 2025 Stephanie Crassweller & VitalityOET

MTHFR, Methylation & Menopause: The Hidden Link Between Your Genes, Detox, and Fat Loss | MMP Ep. 246

The Metabolism and Menopause Podcast