IBCC Episode 48 Angioedema

In this episode of The Internet Book of Critical Care Podcast, Josh and Adam delve into angioedema, distinguishing between histamine-mediated and bradykinin-mediated types, with a focus on the latter. They discuss the diagnosis of angioedema, emphasizing airway inspection techniques and differentiating it from conditions like pharyngeal abscesses. The hosts explore the pathophysiology of bradykinin-mediated angioedema, highlighting the cyclical nature of enzyme activation and the roles of ACE inhibitors, C1 esterase deficiency, and acquired angioedema. They also discuss treatment strategies, including the use of tranexamic acid, C1 inhibitor concentrate, and fresh frozen plasma, and address airway management, intubation indications, and extubation considerations, providing practical advice for critical care scenarios.