07 Feb 2024
1h 51m

Dr. Nir Barzilai: Can This Drug Slow Aging? The Science Behind Metformin

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The Dr. Hyman Show

This podcast explores longevity science, questioning how to extend healthspan and lifespan, featuring Dr. Nir Barzilai, Director of the Institute for Aging Research at Albert Einstein College of Medicine. The discussion challenges traditional reductionist approaches to medicine, advocating for a focus on interconnected "hallmarks of aging" rather than single-target treatments. Barzilai's research on centenarians reveals that genetics play a significant role in longevity, with many subjects possessing protective genes that counteract unhealthy lifestyle choices. The conversation also covers Metformin, including its potential benefits and risks, and the importance of clinical trials to prove aging can be delayed.

Outlines

Part 1: Introduction, Sponsors

Part 2: Biology, Hallmarks of Aging

Part 3: Centenarians, Genetics

Part 4: Lipids, Peptides, Molecular Medicine

Part 5: Metformin, TAME Trial

Part 6: Lifestyle, Supplements, Future Research

Part 7: Personal Protocol, Conclusion

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